Chapter 1 Introduction

Acute Promyelocytic Leukemia (APL), which is a subtype of acute myeloid leukemia (AML), is characterized by the accumulation of immature cells called promyelocytes in the bone marrow and blood. APL is caused by a specific genetic abnormality, a translocation between chromosomes 15 and 17, which results in the formation of a fusion gene between the promyelocytic leukemia (PML) gene on chromosome 15 and the retinoic acid receptor alpha (RARĪ±) gene on chromosome 17. This fusion gene disrupts normal cellular processes, leading to the development of leukemia.

This tutorial includes basic codes in APL-stemness project, including data pre-processing, quality control, cell type annotation, and deconvolution analysis.