Chapter 1 Introduction

p53 is a tumor suppressor protein that plays a crucial role in regulating cell growth, DNA repair, and apoptosis (programmed cell death). Mutant p53 proteins often lose their tumor-suppressive abilities and may acquire oncogenic properties that contribute to cancer development and progression. Therefore, rescuing or restoring the normal function of p53 is a promising strategy for cancer therapy.

There are several approaches to rescue p53 function in cancer cells. One common approach is the use of small molecule compounds that can restore the wild-type conformation and activity of mutant p53. These compounds, known as p53 rescue compounds, work by binding to the mutant p53 protein, inducing conformational changes, and promoting its proper folding and functional activity.

In this tutorial, we provided the source code to evaluate pharmacological rescue of mutant p53.